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Antibiotic A23187, 98%

Catalog No. AAJ63020MA
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Quantity:
10 mg

An antibiotic and calcium ionophore | CAS: 52665-69-7 | C29H37N3O6 | 523.63 g/mol

A23187 (Mixed Calcium-Magnesium Salt) is used in cell activation experiments when calcium dose-response data are not required. Ca-Mg ratio ∼ 1:1. it is widely used as a compound in cell activation. It is used as a highly selective Ca2+ ionophore. it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation. A23187 is a widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intracellular levels of calcium. Visualization of Synaptic Ca2+ Calmodulin-Dependent Protein Kinase II Activity in Living Neurons.

This Thermo Scientific Chemicals brand product was originally part of the Alfa Aesar product portfolio. Some documentation and label information may refer to the legacy brand. The original Alfa Aesar product / item code or SKU reference has not changed as a part of the brand transition to Thermo Scientific Chemicals.

Applications
A23187 (Mixed Calcium-Magnesium Salt) is used in cell activation experiments when calcium dose-response data are not required. Ca-Mg ratio ∼ 1:1. it is widely used as a compound in cell activation. It is used as a highly selective Ca2+ ionophore. it is used in studies of intracellular Ca2+ mediated events. A23187 has been observed to induce cell activation, differentiation or proliferation. In vitro experimentation has shown A23187 to boost ROS generation and platelet fragmentation. A23187 is a widely used ionophore. It has the ability to increase the intracellular concentrations of cations and is widely used to increase the intracellular levels of calcium. Visualization of Synaptic Ca2+ Calmodulin-Dependent Protein Kinase II Activity in Living Neurons.

Solubility
Soluble in DMSO with warming or sonication. Also soluble in ethanol or ethyl acetate

Notes
Store in cool place. Keep container tightly closed in a dry and well-ventilated place. Recommended storage temperature: -20°C. Keep away from strong oxidizing agents.
TRUSTED_SUSTAINABILITY

Specifications

Type Antibiotic A23187
Physical Form Powder
CAS 52665-69-7
Color White to Yellow
Quantity 10 mg
Molecular Formula C29H37N3O6
MDL Number MFCD00151202,MFCD00151202
Beilstein 1096801
Merck Index 14,1639
Synonym Calcimycin; Calcium ionophore A23187
Solubility Information Soluble in DMSO with warming or sonication; Also soluble in ethanol or ethyl acetate
InChI Key HIYAVKIYRIFSCZ-CVXKHCKVSA-N
SMILES CNC1=CC=C2OC(C[C@@H]3OC4(CC[C@@H]3C)O[C@H](C(C)C(=O)C3=CC=CN3)[C@H](C)C[C@H]4C)=NC2=C1C(O)=O
IUPAC Name 5-(methylamino)-2-{[(2S,3S,8S,9R,11R)-3,9,11-trimethyl-8-[1-oxo-1-(1H-pyrrol-2-yl)propan-2-yl]-1,7-dioxaspiro[5.5]undecan-2-yl]methyl}-1,3-benzoxazole-4-carboxylic acid
Molecular Weight (g/mol) 523.63
PubChem CID 97043288
Formula Weight 523.62
Percent Purity 98%
Chemical Name or Material Antibiotic A23187
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Hazard Category H302+H312+H332-H315-H319-H335
Hazard Statement GHS H Statement
H302-H315-H319-H335
Harmful if swallowed.
Causes skin irritation.
Causes serious eye irritation.
May cause respiratory irritation.
Precautionary Statement P261-P264b-P270-P271-P280-P301+P312-P302+P352-P304+P340-P305+P351+P338-P312-P330-P332+P313-P362-P501c
DOTInformation Hazard Class: 6.1; Packaging Group: III
EINECSNumber 258-084-1
RTECSNumber DM4676000
TSCA No
Recommended Storage Keep cold

RUO – Research Use Only

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