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STEMCELL Technologies Mitomycin C, Size: 50 mg
Supplier: STEMCELL Technologies 1001048
Inhibit DNA synthesis and mutagenesis, stimulate genetic recombination, and induce DNA repair (Tomasz. Chem Biol, 1995) with Mitomycin C. This antibiotic, which acts as a double-stranded DNA alkylating agent, covalently cross links DNA, inhibiting DNA synthesis and cell proliferation. It acts by way of reductive activation either through low pH or NAD(P)H:quinone oxidoreductase (DT-diaphorase) or NADH cytochrome c reductase (Mao et al. Chem Biol, 1999; Cummings et al. Biochem Pharmacol, 1998). Mitomycin C can mitotically inactivate mouse embryonic fibroblasts (MEFs) for use as feeder cell layers in embryonic stem cell co-culture systems (Bryja et al. Nat Protoc, 2006). Mitomycin C is supplied as a crystalline solid with ≥ 98% purity; Molecular weight 334.3 g/mol; CAS number 50-07-7. Visit STEMCELL.com for more information and related products.
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