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Cayman Chemical Acitretin, Purity: ≥98%, CAS: 55079-83-9, 100 mg
SDP

Catalog No. 502981620
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A retinoid and an active metabolite of the retinoid etretinate that has antiproliferative activities; binds to CRABP-1 and CRABP-II (Kds = 3 and 15 nM, respectively, for the mouse recombinant proteins) but has low affinity for human recombinant retinoic acid receptor-retinoid X receptor (RAR-RXR) heterocomplexes; inhibits proliferation (IC50 = 6.6 µM) and suppresses TNF-α- and IFN-γ-induced protein levels of STAT1, NF-ĸB, and RANTES in HaCaT keratinocytes when used at 50 µM; inhibits proliferation of HL-60, SCC4, SCC15, and A431, but not MCF-7, cancer cells, at 30 µM; decreases the severity of psoriatic-like skin lesions in K14-VEGF transgenic mice (20 µg per mouse)

Catalog No. 50-298-1620 Supplier Cayman Chemical Supplier No. 20853100 MG
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A retinoid and an active metabolite of the retinoid etretinate that has antiproliferative activities; binds to CRABP-1 and CRABP-II (Kds = 3 and 15 nM, respectively, for the mouse recombinant proteins) but has low affinity for human recombinant retinoic acid receptor-retinoid X receptor (RAR-RXR) heterocomplexes; inhibits proliferation (IC50 = 6.6 µM) and suppresses TNF-α- and IFN-γ-induced protein levels of STAT1, NF-ĸB, and RANTES in HaCaT keratinocytes when used at 50 µM; inhibits proliferation of HL-60, SCC4, SCC15, and A431, but not MCF-7, cancer cells, at 30 µM; decreases the severity of psoriatic-like skin lesions in K14-VEGF transgenic mice (20 µg per mouse)

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