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Cayman Chemical Acolbifene, Purity: ≥98%, CAS: 182167-02-8, 1 mg
SDP

Catalog No. 502995319
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A SERM; inhibits E2-induced transcriptional activity of ERα and ERβ (IC50s = 2 and 0.4 nM, respectively); binds to ERs in cytosol from human breast cancer and non-cancerous uterine cells (Kis = 0.047 and 0.042 nM, respectively); binds to ERs in cytosol from rat uterine cells (IC50 = 0.44 nM) but not to progesterone or androgen receptors in cytosol from rat uterine and ventral prostate cells (IC50s = 22,500 and >10,000 nM, respectively); inhibits E2-stimulated proliferation of T47D, ZR-75-1, and MCF-7 breast cancer cells (IC50s = 0.146, 0.75, and 0.321 nM, respectively); inhibits E1-stimulated tumor growth in a ZR-75-1 human breast cancer xenograft model in ovariectomized mice (50 μg per day); inhibits E1-stimulated endometrial epithelium thickening in vivo in ovariectomized mice (50 μg per day)

Catalog No. 50-299-5319 Supplier Cayman Chemical Supplier No. 239311 MG
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A SERM; inhibits E2-induced transcriptional activity of ERα and ERβ (IC50s = 2 and 0.4 nM, respectively); binds to ERs in cytosol from human breast cancer and non-cancerous uterine cells (Kis = 0.047 and 0.042 nM, respectively); binds to ERs in cytosol from rat uterine cells (IC50 = 0.44 nM) but not to progesterone or androgen receptors in cytosol from rat uterine and ventral prostate cells (IC50s = 22,500 and >10,000 nM, respectively); inhibits E2-stimulated proliferation of T47D, ZR-75-1, and MCF-7 breast cancer cells (IC50s = 0.146, 0.75, and 0.321 nM, respectively); inhibits E1-stimulated tumor growth in a ZR-75-1 human breast cancer xenograft model in ovariectomized mice (50 μg per day); inhibits E1-stimulated endometrial epithelium thickening in vivo in ovariectomized mice (50 μg per day)

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