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Cayman Chemical AKP-11, Purity: ≥95%, CAS: 1220973-37-4, 10 mg
SDP

Catalog No. 502938621
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An S1P1 receptor agonist (EC50 = 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing the human receptor); decreases surface expression of S1P1 and increases phosphorylation of Akt and ERK in CHO cells expressing S1P1-HA at 100 nM; reduces protein levels of IFN-γ and IL-17 in spinal cord tissue and decreases disease severity in a rat model of EAE at 1.3 and 3 mg/kg; decreases peripheral counts of total lymphocytes and total, CD4+, CD8+, and CD26L+ T cells in an EAE rat model, as well as in healthy control animals, at 1.3 mg/kg

Catalog No. 50-293-8621 Supplier Cayman Chemical Supplier No. 2767010 MG
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An S1P1 receptor agonist (EC50 = 0.047 μM for [35S]GTPγS binding to CHO-K1 cell membranes expressing the human receptor); decreases surface expression of S1P1 and increases phosphorylation of Akt and ERK in CHO cells expressing S1P1-HA at 100 nM; reduces protein levels of IFN-γ and IL-17 in spinal cord tissue and decreases disease severity in a rat model of EAE at 1.3 and 3 mg/kg; decreases peripheral counts of total lymphocytes and total, CD4+, CD8+, and CD26L+ T cells in an EAE rat model, as well as in healthy control animals, at 1.3 mg/kg

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