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Cayman Chemical Apilimod, Purity: ≥98%, CAS: 541550-19-0, 5 mg
SDP

Catalog No. 502983352
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An inhibitor of PIKfyve (IC50 = 14 nM); is selective for PIKfyve over 10 other lipid kinases and 31 other protein kinases (IC50s = >9.1 µM for all); inhibits the production of IL-12p40 induced by IFN-γ and LPS or R-837 in isolated human PBMCs (IC50s = 2.4 and 3 nM, respectively) and the production of IL-23 induced by IFN-γ and SAC in isolated human PBMCs (IC50 = 10 nM); prevents infection of Vero E6 cells by SARS-CoV-2 (EC50 = 23 nM); reduces cell viability in a panel of B cell non-Hodgkin lymphoma cell lines (mean IC50 = 142 nM); decreases disease severity in a CD4+CD45Rbhigh T cell transfer mouse model of IBD at 10 mg/kg; decreases disease severity in a mouse model of IRBP1-20-induced experimental autoimmune uveoretinitis

Catalog No. 50-298-3352 Supplier Cayman Chemical Supplier No. 190945 MG
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An inhibitor of PIKfyve (IC50 = 14 nM); is selective for PIKfyve over 10 other lipid kinases and 31 other protein kinases (IC50s = >9.1 µM for all); inhibits the production of IL-12p40 induced by IFN-γ and LPS or R-837 in isolated human PBMCs (IC50s = 2.4 and 3 nM, respectively) and the production of IL-23 induced by IFN-γ and SAC in isolated human PBMCs (IC50 = 10 nM); prevents infection of Vero E6 cells by SARS-CoV-2 (EC50 = 23 nM); reduces cell viability in a panel of B cell non-Hodgkin lymphoma cell lines (mean IC50 = 142 nM); decreases disease severity in a CD4+CD45Rbhigh T cell transfer mouse model of IBD at 10 mg/kg; decreases disease severity in a mouse model of IRBP1-20-induced experimental autoimmune uveoretinitis

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