Cayman Chemical ANTIBODY APX-115 25mg

Supplier:  Cayman Chemical 4111025 MG

An inhibitor of NOX1, NOX2, and NOX4 (Kis = 1.08, 0.57, and 0.63 µM, respectively, for the human enzymes); selective for these enzymes over xanthine oxidase and glucose oxidase (Kis = >100 µM for both); prevents RANKL-induced increases in ROS levels in primary mouse BMDMs at 10 or 20 µM; inhibits GM-CSF- and RANKL-induced primary mouse osteoclast differentiation at 1.1, 3.3, or 10 µM; increases femur bone mass density and strength and reduces femur and tibia resorption areas in OVX mice at 10 mg/kg per day; reduces plasma and urinary levels of 8-isoprostane, plasma levels of insulin, triglycerides, HDL, LDL, and creatinine, urinary levels of albumin, as well as renal fibrosis, in a db/db mouse model of diabetic nephropathy at 60 mg/kg per day

Catalog No. 50-294-2645