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Cayman Chemical ASTX660, Purity: ≥98%, CAS: 1799328-86-1, 10 mg
SDP

Catalog No. 502913942
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A non-peptidomimetic inhibitor of IAP protein-peptide interactions; inhibits the protein-peptide interaction between the IAP1 and XIAP BIR3 domains with a Smac-derived peptide in cell-free assays (IC50s = 50 = 2.8 nM); induces displacement of Smac from XIAP in A375 melanoma cells; induces apoptosis in MDA-MB-231, A375, and SK-MEL-28 cells in a TNF-α-dependent manner; reduces tumor growth in MDA-MB-231 and A375 mouse xenograft models at 20 mg/kg

Catalog No. 50-291-3942 Supplier Cayman Chemical Supplier No. 3661910 MG
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A non-peptidomimetic inhibitor of IAP protein-peptide interactions; inhibits the protein-peptide interaction between the IAP1 and XIAP BIR3 domains with a Smac-derived peptide in cell-free assays (IC50s = 50 = 2.8 nM); induces displacement of Smac from XIAP in A375 melanoma cells; induces apoptosis in MDA-MB-231, A375, and SK-MEL-28 cells in a TNF-α-dependent manner; reduces tumor growth in MDA-MB-231 and A375 mouse xenograft models at 20 mg/kg

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