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Cayman Chemical AZD 3293, Purity: ≥98%, CAS: 1383982-64-6, 10 mg
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Catalog No. 502935709
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An inhibitor of BACE1 and BACE2 (Kis = 0.4 and 0.8 nM, respectively); selective for BACE1 and BACE2 over cathepsin D, γ-secretase, and hERG (IC50s = 3,797, >25,000, and 4,700 nM, respectively); inhibits the secretion of Aβ40 in primary mouse and guinea pig neuronal cultures (IC50s = 0.61 and 0.31 NM, respectively), as well as in SH-SY5Y cells overexpressing human APP (IC50 = 0.08 nM); reduces plasma and brain levels of Aβ40 and brain levels of Aβ42 in mice at 50, 100, and 200 µmol/kg

Catalog No. 50-293-5709 Supplier Cayman Chemical Supplier No. 2493410 MG
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An inhibitor of BACE1 and BACE2 (Kis = 0.4 and 0.8 nM, respectively); selective for BACE1 and BACE2 over cathepsin D, γ-secretase, and hERG (IC50s = 3,797, >25,000, and 4,700 nM, respectively); inhibits the secretion of Aβ40 in primary mouse and guinea pig neuronal cultures (IC50s = 0.61 and 0.31 NM, respectively), as well as in SH-SY5Y cells overexpressing human APP (IC50 = 0.08 nM); reduces plasma and brain levels of Aβ40 and brain levels of Aβ42 in mice at 50, 100, and 200 µmol/kg

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