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Cayman Chemical AZD 3458, Purity: ≥98%, CAS: 2132961-46-5, 10 mg
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Catalog No. 502945432
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A PI3Kγ inhibitor (IC50 = 0.79 nM); selective for PI3Kγ over PI3Kα, PI3Kβ, and PI3Kδ (IC50s = 7.94, >31.62, and 0.316 µM, respectively), PI3KC2α, PI3KC2γ, and PI3KC3 (IC50s = >10, 3.16, and 7.94 µM, respectively), and a panel of 395 kinases at 1 µM but does inhibit PI3KC2β (IC50 = 31.62 nM); reduces LPS-induced increases in BALF neutrophils in a rat model of acute lung inflammation at 0.1, 0.5, and 2.5 mg/kg

Catalog No. 50-294-5432 Supplier Cayman Chemical Supplier No. 4210410 MG
May include imposed supplier surcharges.
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A PI3Kγ inhibitor (IC50 = 0.79 nM); selective for PI3Kγ over PI3Kα, PI3Kβ, and PI3Kδ (IC50s = 7.94, >31.62, and 0.316 µM, respectively), PI3KC2α, PI3KC2γ, and PI3KC3 (IC50s = >10, 3.16, and 7.94 µM, respectively), and a panel of 395 kinases at 1 µM but does inhibit PI3KC2β (IC50 = 31.62 nM); reduces LPS-induced increases in BALF neutrophils in a rat model of acute lung inflammation at 0.1, 0.5, and 2.5 mg/kg

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