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Cayman Chemical ANTIBODY BAY-985 500ug
Supplier: Cayman Chemical 34234500 UG
A dual inhibitor of TBK1 and IKKε (IC50 = 2 nM for both); selective for TBK1 and IKKε over FLT3, RSK4, DRAK1, and ULK1 (IC50s = 123, 276, 311, and 7,390 nM, respectively); inhibits phosphorylation of IRF3 in MDA-MB-231 cells expressing mouse IRF3 (IC50 = 74 nM); inhibits the proliferation of SK-MEL-2 cells in vitro (IC50 = 900 nM); reduces tumor weight in an SK-MEL-2 mouse xenograft model at 200 mg/kg
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