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Cayman Chemical BC-1215, Purity: ≥98%, CAS: 1507370-20-8, 25 mg
SDP

Catalog No. 502964058
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An inhibitor of FBXO3 (IC50 = 0.9 μg/mL for Il-1β release); decreases FBXO3-FBXL2 interaction in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2; lowers expression of TRAF1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated PBMCs; reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis when administered at a dose of 100 μg, i.p., per animal; reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema

Catalog No. 50-296-4058 Supplier Cayman Chemical Supplier No. 2196425 MG
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An inhibitor of FBXO3 (IC50 = 0.9 μg/mL for Il-1β release); decreases FBXO3-FBXL2 interaction in a dose-dependent manner and prevents FBXO3-dependent ubiquitination of FBXL2; lowers expression of TRAF1-6 without affecting TRAF1-6 mRNA levels in resting and LPS-stimulated PBMCs; reduces plasma levels of the inflammatory cytokines Il-6, Tnf, and Il-1β and decreases peritoneal bacteria counts in a mouse model of cecal ligation and puncture-induced sepsis when administered at a dose of 100 μg, i.p., per animal; reduces inflammation in mouse models of DSS-induced colitis, paw edema, and ear edema

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