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Cayman Chemical ANTIBODY BSP-16 1mg
Supplier: Cayman Chemical 379921 MG
A STING agonist; binds to STING (Kd = 23 µM); induces the production of IFN-β, IL-6, and CXCL10 in THP-1 cells at 10, 25, and 50 µM; induces phosphorylation of IRF3 and TBK1 in THP-1 cells at 50 µM; reduces tumor volume in an MC-38 murine carcinoma model and induces tumor regression in a CT26 murine colorectal carcinoma model at 15 and 30 mg/kg; prevents tumor cell re-challenge-induced tumor formation in a CT26 murine carcinoma model; reduces tumor volume and increases the number of activated CD8+ T cells and NK cells in a 4T1 murine mammary carcinoma model at 20 mg/kg
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