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Cayman Chemical ANTIBODY BX-320 500ug

Supplier: Cayman Chemical 31229500 UG
An inhibitor of PDK1 (IC50 = 30 nM); selective for PDK1 over a panel of 10 additional kinases (IC50s = >820 nM for all); inhibits Akt and p70S6K1 phosphorylation in PC3 cells (IC50s = 1-3 µM); induces apoptosis in, and inhibits the growth of, MDA-MB-468 breast cancer cells (IC50s = 0.5 and 0.6 µM, respectively), as well as inhibits cell growth in a panel of cancer cells (IC50s = 0.12-1.2 µM); inhibits the growth of lung tumors in a LOX melanoma mouse model of blood-borne metastasis at 200 mg/kg
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