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Cayman Chemical BYL719, Purity: ≥98%, CAS: 1217486-61-7, 50 mg
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Catalog No. 502980440
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An inhibitor of PI3Kα (IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively); selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all); reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model at 12.5, 25, and 50 mg/kg; also reduces tumor burden in THP-1 AML and MCF-7 breast cancer mouse xenograft models

Catalog No. 50-298-0440 Supplier Cayman Chemical Supplier No. 1698650 MG
May include imposed supplier surcharges.
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An inhibitor of PI3Kα (IC50s = 4.6, 4, and 4.8 nM for wild-type, E545K mutant, and H1047R mutant PI3K, respectively); selective for PI3Kα over PI3Kβ, PI3Kδ, PI3Kγ, and PI4Kβ (IC50s = 1,156, 290, 250, and 581 nM, respectively), as well as VPS34, mTOR, DNA-PK, and ATR (IC50s = >9,100 nM for all); reduces tumor volume in a PI3Kα-dependent Rat1-myr-p110α mouse xenograft model at 12.5, 25, and 50 mg/kg; also reduces tumor burden in THP-1 AML and MCF-7 breast cancer mouse xenograft models

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