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Cayman Chemical C25-140, Purity: ≥98%, CAS: 1358099-18-9, 10 mg
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Catalog No. 502917134
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An inhibitor of the TRAF6-Ubc13 protein-protein interaction (IC50 = 2.6 µM); selectively inhibits the TRAF6-Ubc13 interaction over the interactions between Ubc13- OTUB1 and Ubc13-Uev1a; selectively inhibits TRAF6-dependent ubiquitination over a panel of various E3 ligase/E2 enzymes, but does inhibit cIAP1 and E1/E2 enzymes in cell-free assays at 30 µM; reduces IL-1β-induced activation of NF-κB in MEFs at 50 µM; topical application reduces scaling and erythema in a mouse model of imiquimod-induced psoriasis; decreases disease severity in a mouse model of collagen-induced arthritis from 6-14 mg/kg twice per day; reduces alveolar septal thickening, pulmonary edema, and inflammatory cell infiltration in BALF in a mouse model of lung injury induced by mechanical ventilation with high tidal volumes

Catalog No. 50-291-7134 Supplier Cayman Chemical Supplier No. 3966910 MG
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An inhibitor of the TRAF6-Ubc13 protein-protein interaction (IC50 = 2.6 µM); selectively inhibits the TRAF6-Ubc13 interaction over the interactions between Ubc13- OTUB1 and Ubc13-Uev1a; selectively inhibits TRAF6-dependent ubiquitination over a panel of various E3 ligase/E2 enzymes, but does inhibit cIAP1 and E1/E2 enzymes in cell-free assays at 30 µM; reduces IL-1β-induced activation of NF-κB in MEFs at 50 µM; topical application reduces scaling and erythema in a mouse model of imiquimod-induced psoriasis; decreases disease severity in a mouse model of collagen-induced arthritis from 6-14 mg/kg twice per day; reduces alveolar septal thickening, pulmonary edema, and inflammatory cell infiltration in BALF in a mouse model of lung injury induced by mechanical ventilation with high tidal volumes

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