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Cayman Chemical ANTIBODY CA-074 500ug

Supplier: Cayman Chemical 24679500 UG
A selective cathepsin B inhibitor (Kis = 0.0087, 75, and 233 μM for rat cathepsin B, H, and L, respectively); inhibits degradation of DQ-collagen IV and DQ-collagen I in 4T1.2 breast cancer cells; reduces the number of lung and bone metastases in a 4T1.2 murine mammary cancer model at 50 mg/kg; reduces mercury-induced increases in expression of TNF-α, IL-1β, and the inflammasome component NRLP3 and decreases the severity of mercury-induced skin induration in mice at 0.1 and 0.2 mg/kg; reduces ischemia-induced hippocampal neuron cell death in monkeys
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