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Cayman Chemical ANTIBODY CM-272 1mg
Supplier: Cayman Chemical 259481 MG
An inhibitor of G9a, GLP, and DNA methyltransferases (IC50s = 8, 2, 382, 85, and 1,200 nM for G9a, GLP, DNMT1, DNMT3A, and DNMT3B, respectively); inhibits the growth of, and induces apoptosis in, hematological cancer cell lines (GI50s = 218-455 nM); induces the expression of IFN-stimulated genes and immunologic cell death markers in hematological cancer cell lines; reduces tumor growth in MV4-11 and EGI-1 mouse xenograft models at 2.5 mg/kg; increases survival in CEMO-1 and RT112 mouse xenograft models at 2.5 and 5 mg/kg, respectively
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