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Cayman Chemical ANTIBODY Darusentn 1mg

Supplier: Cayman Chemical 360341 MG
An ETA receptor antagonist (Ki = 13 nM in rat aortic vascular smooth muscle cells); inhibits ET-1-induced contractions in isolated rat aortic rings and mesenteric microvessels (pA2s = 8.1 and 7.97, respectively); decreases systolic blood pressure in DOCA-salt hypertensive rats at 50 mg/kg; decreases MAP and LVDP in normotensive pigs at 1 and 5 mg/kg; reduces myocardial infarct size as a percentage of the area at risk in a porcine model of LAD coronary artery ligation-induced ischemia-reperfusion injury
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