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Cayman Chemical DCPIB, Purity: ≥98%, CAS: 82749-70-0, 5 mg
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Catalog No. 502949831
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A VRAC inhibitor; inhibits ICl,swell in bovine pulmonary artery endothelial cells (IC50 = 4.1 µM); inhibits LRRC8A (IC50 = 20.9 µM) and inhibits sphingosine-1-phosphate-induced cGAMP uptake by LRRC8A in TIME cells at 20 µM; inhibits K2P18.1/TRESK, K2P3.1/TASK1, and K2P9.1/TASK3 in COS-7 cells expressing the human channels (IC50s = 0.14, 0.95, and 50.72 µM, respectively); activates K2P2.1/TREK1 and K2P4.1/TRAAK channels in COS-7 cells expressing the human channels at 10 µM; intracisternal administration reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia induced by MCAO at 20 µg/kg

Catalog No. 50-294-9831 Supplier Cayman Chemical Supplier No. 340645 MG
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A VRAC inhibitor; inhibits ICl,swell in bovine pulmonary artery endothelial cells (IC50 = 4.1 µM); inhibits LRRC8A (IC50 = 20.9 µM) and inhibits sphingosine-1-phosphate-induced cGAMP uptake by LRRC8A in TIME cells at 20 µM; inhibits K2P18.1/TRESK, K2P3.1/TASK1, and K2P9.1/TASK3 in COS-7 cells expressing the human channels (IC50s = 0.14, 0.95, and 50.72 µM, respectively); activates K2P2.1/TREK1 and K2P4.1/TRAAK channels in COS-7 cells expressing the human channels at 10 µM; intracisternal administration reduces infarct area and neurological deficit scores in a rat model of cerebral ischemia induced by MCAO at 20 µg/kg

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