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Cayman Chemical ANTIBODY DEL-22379 10mg
Supplier: Cayman Chemical 2243310 MG
An inhibitor of ERK dimerization (IC50 = ~0.5 μM for disruption of EGF-induced co-immunoprecipitation of ERK); has no effect on ERK phosphorylation or kinase activity (IC50s = >10 μM); inhibits cell growth in a panel of melanoma and colorectal cancer cell lines (IC50s = 150-400 nM); inhibits ERK dimerization in liver extract and tumor tissue and inhibits tumor progression in an A375 mouse xenograft model at 15 mg/kg; reduces tumor growth in a BRAF mutant colorectal cancer PDX mouse model
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