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Cayman Chemical Dofequidar, Purity: ≥98%, CAS: 129716-58-1, 1 mg
SDP

Catalog No. 502989885
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A quinoline derivative and inhibitor of multidrug resistance; inhibits P-glycoprotein in a photolabeling assay at 100 μM; increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding MRP at 10 μM; restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells; increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls at 80 mg/kg twice per day when administered in combination with vincristine

Catalog No. 50-298-9885 Supplier Cayman Chemical Supplier No. 309251 MG
May include imposed supplier surcharges.
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A quinoline derivative and inhibitor of multidrug resistance; inhibits P-glycoprotein in a photolabeling assay at 100 μM; increases intracellular accumulation of [3H]-vincristine in HL-60R cells endogenously expressing the gene encoding MRP at 10 μM; restores susceptibility to vincristine- or doxorubicin-induced cytotoxicity in vincristine-resistant P388, vincristine-resistant K562, and doxorubicin-resistant K562 cells; increases survival in a vincristine-resistant P388 murine leukemia model compared with untreated controls at 80 mg/kg twice per day when administered in combination with vincristine

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