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Cayman Chemical DUB-IN-2, Purity: ≥95% (mixture of cis/trans isomers), CAS: 924296-19-5, 10 mg
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Catalog No. 502912876
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An inhibitor of USP8 (IC50 = 280 nM); selective for USP8 over USP7 (IC50 = >100 µM); increases the level of PD-L1 in H460 cells at 2 µM and PC-9 cells at 2 and 4 µM; decreases tumor weight, tumor size, and lung metastasis and increases CD8+ T cell numbers within the primary tumor in a 4T1 murine mammary carcinoma model at 1 mg/kg every other day, i.p., when combined with an anti-PD-L1 antibody and paclitaxel

Catalog No. 50-291-2876 Supplier Cayman Chemical Supplier No. 3622910 MG
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An inhibitor of USP8 (IC50 = 280 nM); selective for USP8 over USP7 (IC50 = >100 µM); increases the level of PD-L1 in H460 cells at 2 µM and PC-9 cells at 2 and 4 µM; decreases tumor weight, tumor size, and lung metastasis and increases CD8+ T cell numbers within the primary tumor in a 4T1 murine mammary carcinoma model at 1 mg/kg every other day, i.p., when combined with an anti-PD-L1 antibody and paclitaxel

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