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Cayman Chemical FGTI-2734, Purity: ≥95%, CAS: 1247018-19-4, 5 mg
SDP

Catalog No. 502916458
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A dual inhibitor of FTase and GGTase I (IC50s = 250 and 520 nM, respectively); inhibits prenylation of H-Ras and Rap1A (IC50s = 88.7 and 2,700 nM, respectively) in oncogenic H-Ras-transformed NIH3T3 cells; inhibits membrane localization of K-Ras in MIA PaCa-2 and H460 cancer cells at 10 and 30 µM; reduces tumor growth, increases intratumoral expression of p53, induces intratumoral apoptosis, and decreases intratumoral HDJ2 farnesylation and Rap1A geranylgeranylation in PDX mouse models of mutant KRAS-expressing pancreatic cancer at 50 and 100 mg/kg per day

Catalog No. 50-291-6458 Supplier Cayman Chemical Supplier No. 376945 MG
May include imposed supplier surcharges.
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A dual inhibitor of FTase and GGTase I (IC50s = 250 and 520 nM, respectively); inhibits prenylation of H-Ras and Rap1A (IC50s = 88.7 and 2,700 nM, respectively) in oncogenic H-Ras-transformed NIH3T3 cells; inhibits membrane localization of K-Ras in MIA PaCa-2 and H460 cancer cells at 10 and 30 µM; reduces tumor growth, increases intratumoral expression of p53, induces intratumoral apoptosis, and decreases intratumoral HDJ2 farnesylation and Rap1A geranylgeranylation in PDX mouse models of mutant KRAS-expressing pancreatic cancer at 50 and 100 mg/kg per day

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