Cayman Chemical ANTIBODY GSK-F1 25mg

Supplier:  Cayman Chemical 4136625 MG

A PROTAC that drives Bcl-xL degradation selectively induces degradation of Bcl-xL in MOLT-4 cells (DC50 63 nM Dmax 90.8 ) over washed isolated human platelets (Dmax 26 at 3 UM) selectively binds to Bcl-xL and Bcl-2 over Bcl-W (Kis 12.82 1.82 and 300.9 nM respectively) but does not induce degradation of Bcl-2 or Bcl-W in RS411 cells at 1 UM cytotoxic to MOLT-4 cells but not washed isolated human platelets (EC50s 0.052 and 3 UM respectively) induces cleavage of caspase-3 in MOLT-4 cells at 100 and 300 nM reduces tumor volume and weight in a MOLT-4 mouse xenograft model at 15 mg/kg acts synergistically with ABT-199 in an NCI H146 mouse xenograft model and docetaxel in an MDA-MB-231 mouse xenograft model

Catalog No. 50-294-5768