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Cayman Chemical GSK547, Purity: ≥98%, CAS: 2226735-55-1, 25 mg
SDP

Catalog No. 502917769
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A RIPK1 inhibitor (IC50 = 31 nM); selective for RIPK1 over a panel of 371 kinases at 10 µM; increases survival and reduces tumor volume and the number of liver metastases in a P48Cre KrasG12D orthotopic mouse model of progressive PDA at 100 mg/kg; adoptive transfer of tumor-infiltrating T cells isolated from GSK547-treated mice protects against orthotopic PDA tumor growth in mice; reduces plasma levels of TNF-α and IL-1β and decreases macrophage infiltration in aortic sinus lesions in an ApoESA/SA mouse model of early-phase atherogenesis

Catalog No. 50-291-7769 Supplier Cayman Chemical Supplier No. 3734725 MG
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A RIPK1 inhibitor (IC50 = 31 nM); selective for RIPK1 over a panel of 371 kinases at 10 µM; increases survival and reduces tumor volume and the number of liver metastases in a P48Cre KrasG12D orthotopic mouse model of progressive PDA at 100 mg/kg; adoptive transfer of tumor-infiltrating T cells isolated from GSK547-treated mice protects against orthotopic PDA tumor growth in mice; reduces plasma levels of TNF-α and IL-1β and decreases macrophage infiltration in aortic sinus lesions in an ApoESA/SA mouse model of early-phase atherogenesis

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