Promotional price valid on web orders only. Your contract pricing may differ. Interested in signing up for a dedicated account number?
Learn More
  1. Home
  2. Products
  3. 502944401

Cayman Chemical ANTIBODY H3B-8800 500ug
SDP

Supplier:  Cayman Chemical 42106500 UG

Encompass_Preferred

An inhibitor of the SF3B complex; binds to SF3B complexes containing wild-type SF3B (IC50 = 1.4 nM) or various SF3B mutations (IC50s = 0.3-1.8 nM); inhibits SF3B1-induced splicing of canonical and aberrant pre-mRNA junctions in HEK293T nuclear extracts overexpressing SF3B1K700E; selectively inhibits the growth of, and induces apoptosis in, Panc 05.04 pancreatic cancer cells expressing mutant SF3B over Panc 10.05, HAPF-II, and CFPAC-1 pancreatic cancer cells expressing wild-type SF3B in a concentration-dependent manner; reduces tumor growth in a K562 mouse xenograft model using K562 cells expressing wild-type SF3B1 at 8 mg/kg and K562 cells expressing SF3B1K700E at 2, 4, or 8 mg/kg

Catalog No. 50-294-4401


May include imposed supplier surcharges.
Only null left
Add to Cart

Product Title
Select an issue

By clicking Submit, you acknowledge that you may be contacted by Fisher Scientific in regards to the feedback you have provided in this form. We will not share your information for any other purposes. All contact information provided shall also be maintained in accordance with our Privacy Policy.