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Cayman Chemical ANTIBODY HA-15 10mg
Supplier: Cayman Chemical 3577510 MG
An inhibitor of GRP78; binds to GRP79 in a cell-free assay and increases the expression of the genes encoding the UPR proteins EIF2AK3, IRE1α, ATF6, DDIT3, and XBP1, as well as the apoptosis-associated genes JUN and BCL2 and the autophagy marker gene LC3; decreases the viability of A375 melanoma cells (IC50 = 2.5 µM); reduces tumor volume and induces intratumor apoptosis and autophagy in an A375 mouse xenograft model at 0.7 mg/animal per day; increases osteogenesis and reduces bone loss in a mouse model of ovariectomy-induced osteoporosis
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