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Cayman Chemical ANTIBODY IHCH-7079 5mg
SDP

Supplier:  Cayman Chemical 419885 MG

Encompass_Preferred

A dual inhibitor of VEGFR and FGFR inhibits VEGFR1 VEGFR2 and VEGFR3 (IC50s 7 25 and 10 nM respectively) and FGFR1 and FGFR2 (IC50s 17.5 and 82.5 nM respectively) selective for VEGFR1-3 and FGFR1-2 over FGFR3 and FGFR4 (IC50s 237.5 and 1000 nM respectively) as well c-Kit PDGFRa and PDGFRB (IC50s 456 175 and 525 nM respectively) but does inhibit FMS (IC50 5 nM) inhibits VEGF- or bFGF-induced HUVEC proliferation (IC50s 40 and 50 nM respectively) but inhibits the proliferation of A2780 A498 and SN12KI cancer cells only at higher concentrations (IC50s 27.7 19.6 and 12.79 UM respectively) reduces tumor growth in various mouse xenograft models in a dose-dependent manner completely inhibits bFGF-induced angiogenesis in a Matrigel plug assay in mice at 20 mg/kg

Catalog No. 50-294-3364


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