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Cayman Chemical IMR-1, Purity: ≥95% (mixture of isomers), CAS: 310456-65-6, 5 mg
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Catalog No. 502938667
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An inhibitor of Maml1 recruitment to chromatin; binds to the intracellular domain of Notch (KD = 11 µM) and prevents transcription of Notch target genes by inhibiting the recruitment of Maml1 to chromatin; inhibits colony formation in Notch-dependent cell lines but not Notch-independent cell lines at 15 and 45 µM; decreases the expression of Notch target genes and reduces tumor growth in a patient-derived esophageal adenocarcinoma mouse xenograft model at 15 mg/kg

Catalog No. 50-293-8667 Supplier Cayman Chemical Supplier No. 279205 MG
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An inhibitor of Maml1 recruitment to chromatin; binds to the intracellular domain of Notch (KD = 11 µM) and prevents transcription of Notch target genes by inhibiting the recruitment of Maml1 to chromatin; inhibits colony formation in Notch-dependent cell lines but not Notch-independent cell lines at 15 and 45 µM; decreases the expression of Notch target genes and reduces tumor growth in a patient-derived esophageal adenocarcinoma mouse xenograft model at 15 mg/kg

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