Cayman Chemical ANTIBODY JG-2016 25mg

Supplier:  Cayman Chemical 4187625 MG

A HAT1 inhibitor (IC50 = 14.8 µM); selective for HAT1 over KAT2A and p300/CBP-associated factor (PCAF), for which it has no activity, KAT5, KAT6B, and KAT7 (IC50s = >100, >100, and 84.82 µM, respectively), CBP, and p300 (IC50s = 90.41 and 74.25 µM, respectively); reduces acetylation of H4K5 and H4K12 in hTert-HME1 mammary epithelial cells at 20 µM; reduces the growth of HCC1806 and A549 cells (EC50s = 10.4 and 1.9 µM, respectively); reduces intratumoral H4K12 acetylation in an A549 mouse xenograft model in a dose-dependent manner; reduces tumor growth in an A549 mouse xenograft model at 50 and 100 mg/kg once every three days

Catalog No. 50-294-2620