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Cayman Chemical JX06, Purity: ≥98%, CAS: 729-46-4, 10 mg
SDP

Catalog No. 502910532
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An irreversible PDHK inhibitor (IC50s = 49, 101, and 313 nM for PDHK1, PDHK2, and PDHK3, respectively); selective for PDHK1-3 over PDHK4 (IC50 = >10 µM) and 322 other kinases at 10 µM but does inhibit FAK in a cell-free assay but not in a cell-based assay; increases ROS production and induces apoptosis in cancer cells with a high ECAR:OCR ratio; reduces the level of glycolysis metabolites in NCI H929 multiple myeloma cells at 0.25 µM; reduces tumor growth in an A549 mouse xenograft model

Catalog No. 50-291-0532 Supplier Cayman Chemical Supplier No. 3485010 MG
May include imposed supplier surcharges.
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An irreversible PDHK inhibitor (IC50s = 49, 101, and 313 nM for PDHK1, PDHK2, and PDHK3, respectively); selective for PDHK1-3 over PDHK4 (IC50 = >10 µM) and 322 other kinases at 10 µM but does inhibit FAK in a cell-free assay but not in a cell-based assay; increases ROS production and induces apoptosis in cancer cells with a high ECAR:OCR ratio; reduces the level of glycolysis metabolites in NCI H929 multiple myeloma cells at 0.25 µM; reduces tumor growth in an A549 mouse xenograft model

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