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Cayman Chemical ANTIBODY KI-696 10mg
Supplier: Cayman Chemical 4203910 MG
A Keap1-Nrf2 protein-protein interaction inhibitor; binds to the Keap1 Kelch domain (Kd = 1.3 nM) and increases the accumulation of Nrf2 in isolated human bronchial epithelial cells in a concentration-dependent manner; increases the expression of NQO1, GCLM, HMOX1, and TXNRD1 in bronchial epithelial cells isolated from patients with COPD (EC50s = 22, 36, 16, and 27 nM, respectively); increases lung expression of Nqo1, Hmox1, and Txnrd1 in rats at 50 µmol/kg
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