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Cayman Chemical KW 2449, Purity: ≥98%, CAS: 1000669-72-6, 25 mg
SDP

Catalog No. 502986349
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A multi-kinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase (IC50s = 6.6, 14, 4, and 48 nM, respectively); has growth inhibitory activity against leukemia cells expressing FLT3 with activating mutations (GI50s = 11-46 nM); suppresses phosphorylation of FLT3 and STAT5 in MOLM-13 cells in a dose-dependent manner in vitro; inhibits colony formation of human primary AML cells with wild-type or activated mutant FLT3; induces MOLM-13 xenograft regression in a dose-dependent manner in vivo

Catalog No. 50-298-6349 Supplier Cayman Chemical Supplier No. 2220725 MG
May include imposed supplier surcharges.
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A multi-kinase inhibitor of FLT3, ABL, ABL-T315I, and Aurora kinase (IC50s = 6.6, 14, 4, and 48 nM, respectively); has growth inhibitory activity against leukemia cells expressing FLT3 with activating mutations (GI50s = 11-46 nM); suppresses phosphorylation of FLT3 and STAT5 in MOLM-13 cells in a dose-dependent manner in vitro; inhibits colony formation of human primary AML cells with wild-type or activated mutant FLT3; induces MOLM-13 xenograft regression in a dose-dependent manner in vivo

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