Cayman Chemical ANTIBODY LMT-28 10mg

Supplier:  Cayman Chemical 4083710 MG

An inhibitor of the gp130-IL-6/IL6Rα protein-protein interaction; binds to gp130 (Kd = 7.4 µM) and selectively inhibits IL-6-induced STAT3 phosphorylation over leukemia inhibitor factor- or phorbol 12-myristate 13-acetate-induced STAT3 phosphorylation in HepG2 cells at 10, 30, or 100 µM; reduces IL-6-induced increases in the viability of GM-CSF-starved TF-1 leukemia cells at 10 to 1,000 nM; inhibits the LPS- and AGE-induced increases in mRNA encoding Rankl, as well as inhibits increases in the phosphorylation levels of gp130, Stat3, and Jak2, in mouse MC3T3-E1 osteoblasts at 100 nM; decreases joint and paw swelling, as well as serum levels of COMP, SAP, and anti-collagen II antibodies, in a mouse model of collagen-induced arthritis at 0.25 mg/kg per day; reduces bone resorption height and volume in a rat model of type 2 diabetes peri-implantitis induced by LPS, P. gingivalis, and a high-fat and high-sugar diet at 0.23 mg/kg per day p.o.

Catalog No. 50-294-5753