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Cayman Chemical ANTIBODY LY2801653 50mg
Supplier: Cayman Chemical 2597850 MG
A MET kinase inhibitor (Ki = 2 nM); inhibits MST1R, Axl, MNK1/2, FLT3, DDR1, and DDR2 (IC50s = 11, 2, 7, 7, 0.1, and 7 nM, respectively); inhibits HGF-induced MET autophosphorylation in H460 and S114 cells (IC50s = 35.2 and 59.2 nM, respectively) and inhibits growth of Ba/F3 cells transfected with MET-activating mutations (IC50s = 12-248 nM); completely blocks cell scattering induced by HGF in DU145 cells at 0.01-10 µM; reduces tumor growth in MET autocrine (U-87MG) and MET over-expression (H441) mouse xenograft models at 4 and 12 mg/kg
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