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Cayman Chemical MD2-IN-1, Purity: ≥98%, CAS: 111797-22-9, 5 mg
SDP

Catalog No. 502916230
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A chalcone derivative and an inhibitor of the MD-2-LPS interaction; inhibits the interaction between MD-2 and LPS in a cell-free assay at 0.1 µM; inhibits LPS-induced increases in the levels of Tnf-α and Il-6 secreted from isolated and washed MPMs (IC50s = 4.27 and 2.09 µM, respectively); inhibits LPS-induced Nf-κB DNA binding in MPMs at 5 and 20 µM; inhibits the growth of various cancer cells (GI50s = 0.019-0.32 µM, respectively); reduces tumor volume and weight in a HeLa cervical mouse xenograft model at 10 mg/kg for three days; prevents LPS-induced increases in BALF total protein levels and CD68+ macrophage and neutrophil infiltration in a mouse model of LPS-induced acute lung injury at 20 mg/kg per day; reduces MPO activity in isolated neutrophils in the same model

Catalog No. 50-291-6230 Supplier Cayman Chemical Supplier No. 383235 MG
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A chalcone derivative and an inhibitor of the MD-2-LPS interaction; inhibits the interaction between MD-2 and LPS in a cell-free assay at 0.1 µM; inhibits LPS-induced increases in the levels of Tnf-α and Il-6 secreted from isolated and washed MPMs (IC50s = 4.27 and 2.09 µM, respectively); inhibits LPS-induced Nf-κB DNA binding in MPMs at 5 and 20 µM; inhibits the growth of various cancer cells (GI50s = 0.019-0.32 µM, respectively); reduces tumor volume and weight in a HeLa cervical mouse xenograft model at 10 mg/kg for three days; prevents LPS-induced increases in BALF total protein levels and CD68+ macrophage and neutrophil infiltration in a mouse model of LPS-induced acute lung injury at 20 mg/kg per day; reduces MPO activity in isolated neutrophils in the same model

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