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Cayman Chemical MLN2238, Purity: ≥95%, CAS: 1072833-77-2, 10 mg
SDP

Catalog No. 502980076
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A 20S proteasome inhibitor (IC50 = 3.4 nM in a cell-free assay for the β5 subunit) and an active metabolite of MLN9708; selective for the β5 subunit over the β1 and β2 subunits (IC50s = 31 and 3,500 nM, respectively); binds caseinolytic protease P (Kd = 5,700 nM); prevents MRSA-induced hemolysis of isolated ovine erythrocytes (EC50 = 3,600 nM); inhibits the proliferation of A375, H460, HCT116, and HT-29 cells (IC50s = 20, 58, 19, and 52 nM, respectively); inhibits osteoclastogenesis in PBMCs isolated from patients with multiple myeloma (IC50 = 4.8 nM); reduces tumor growth in a CWR22 prostate cancer mouse xenograft model at 14 mg/kg

Catalog No. 50-298-0076 Supplier Cayman Chemical Supplier No. 1838510 MG
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A 20S proteasome inhibitor (IC50 = 3.4 nM in a cell-free assay for the β5 subunit) and an active metabolite of MLN9708; selective for the β5 subunit over the β1 and β2 subunits (IC50s = 31 and 3,500 nM, respectively); binds caseinolytic protease P (Kd = 5,700 nM); prevents MRSA-induced hemolysis of isolated ovine erythrocytes (EC50 = 3,600 nM); inhibits the proliferation of A375, H460, HCT116, and HT-29 cells (IC50s = 20, 58, 19, and 52 nM, respectively); inhibits osteoclastogenesis in PBMCs isolated from patients with multiple myeloma (IC50 = 4.8 nM); reduces tumor growth in a CWR22 prostate cancer mouse xenograft model at 14 mg/kg

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