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Cayman Chemical MSC2530818, Purity: ≥98%, CAS: 1883423-59-3, 10 mg
SDP

Catalog No. 502989132
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A Cdk8 inhibitor (IC50 = 2.6 nM); selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit GSK3α (IC50 = 691 nM); inhibits STAT1 phosphorylation in SW620 colorectal cancer cells (IC50 = 8 nM); inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays); reduces tumor growth in a SW620 mouse xenograft model at 50 and 100 mg/kg

Catalog No. 50-298-9132 Supplier Cayman Chemical Supplier No. 2966910 MG
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A Cdk8 inhibitor (IC50 = 2.6 nM); selective for Cdk8 over a panel of 264 kinases at 1 µM but does inhibit GSK3α (IC50 = 691 nM); inhibits STAT1 phosphorylation in SW620 colorectal cancer cells (IC50 = 8 nM); inhibits Wnt-dependent transcription in LS 174T, COLO 205, and PA-1 cancer cells (IC50s = 32, 9, and 52 nM, respectively, in luciferase reporter assays); reduces tumor growth in a SW620 mouse xenograft model at 50 and 100 mg/kg

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