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Cayman Chemical ANTIBODY NCB-0846 5mg
Supplier: Cayman Chemical 332685 MG
A TNIK inhibitor (IC50 = 21 nM); selective for TNIK over a panel of 46 kinases but does inhibit FLT3, JAK3, PDGFRα, TrkA, Cdk2/CycA2, and HGK by >80% at 100 nM; inhibits phosphorylation of TCF4 and autophosphorylation of TNIK in cell-based assays at 3 µM; inhibits the growth and colony formation of HCT116 cells in two-dimensional growth and soft-agar assays, respectively, as well as reduces tumor growth in an HCT116 mouse xenograft model; reduces tumor growth in PDX mouse models of colon cancer at 50 and 100 mg/kg
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