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Cayman Chemical ANTIBODY NSC 102533 5mg

Supplier: Cayman Chemical 424355 MG
A P2X7 receptor antagonist; inhibits ATP-induced dye uptake in HEK293 cells expressing human purinergic P2X7 receptors (IC50 = 22.4 nM); inhibits common lancehead (B. atrox) venom proteolysis in a concentration-dependent manner; inhibits ATP-induced IL-1ß secretion in human THP-1 monocytes and primary mouse peritoneal macrophages (IC50s = 9.8 and 11.2 nM, respectively); inhibits common lancehead (B. atrox) and jararaca (B. jararaca) venom-induced skin hemorrhage in mice when intradermally administered at 3 mg/kg; inhibits carrageenan-induced paw edema in mice at 0.01 to 1 mg/kg
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