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Cayman Chemical ANTIBODY NSC 207895 10mg
Supplier: Cayman Chemical 2794910 MG
An inhibitor of MDMX; decreases MDMX promoter activity in a reporter assay in a concentration-dependent manner; decreases the expression and protein levels of MDMX and increases the expression of the p53 target gene CDKN1 (p21) in MCF-7 cells overexpressing MDMX at 5 µmol/L; induces apoptosis and decreases cell viability in MCF-7 cells in a p53-dependent manner at 5 µmol/L; induces p53-independent apoptosis in wild-type, mutated, and truncated p53 Ewing sarcoma cell lines (IC50s = 98.9-1,613, 236-299, and 121-396 nM, respectively) selectively over wild-type and p53-null osteosarcoma cells (IC50s = 3,690-5,416 and 2,143 nM, respectively)
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