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Cayman Chemical ANTIBODY NSC 319726 10mg
Supplier: Cayman Chemical 2370110 MG
A p53 reactivator; selectively inhibits growth of human tumor cell lines containing mutant p53 over those containing wild-type p53 (IC50s = 0.1-1 and >10 μM, respectively); induces apoptosis in TOV112D (p53R175H), but not OVCAR3 (p53R248W) or SKOV3 (p53-/-), cells at a concentration of 1 μM; restores a wild-type conformation to human p53175 and mouse p53R172 mutant proteins and induces expression of p53 target genes in TOV112D cells; inhibits tumor growth in TOV112D, but not H460 (p53+/+), mouse xenograft model when administered at a dose of 1 mg/kg; has broad-spectrum antifungal activity (MIC50s = 0.1-2 μg/ml against a panel of pathogenic fungi) with >800-fold selectivity for fungi over human HUH-7 and HepG2 cells
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