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Cayman Chemical ANTIBODY NSC 668036 10mg
Supplier: Cayman Chemical 2349910 MG
An inhibitor of the Dvl PDZ domain (Kd = 240 μM for mouse Dvl1 PDZ domain); reduces expression of the Wnt target gene, Siamois, in Xenopus embryos and inhibits the ability of injected Wnt3A to induce formation of a secondary axis (180 ng); inhibits proliferation of NIH/3T3 fibroblasts, restrains their migration in a scratch assay, and blocks the accelerating effect of TGF-β on fibroblast migration (>10 μM); reduces the severity of bleomycin-induced pulmonary fibrosis and expression of α-SMA collagen I, TGF-β, and β-catenin in lung in mice (5 mg/kg per day for 14 days)
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