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Cayman Chemical NVP-BKM120, Purity: ≥95%, CAS: 944396-07-0, 5 mg
SDP

Catalog No. 502951771
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An inhibitor of the class I PI3K isoforms p110α (IC50 = 52 nM) and p110β (IC50 = 166 nM); selective for these isoforms over the class III PI3K Vps34 (IC50 = 2,410 nM), mTOR (IC50 = 2,866 nM), PI4Kβ (IC50 = >25,000 nM), and a variety of kinases (IC50s = >10,000 nM); inhibits proliferation of human tumor and glioma cell lines, with p53 wild-type glioma cells more sensitive than p53 mutant/deleted glioma cells (IC50s = 1.28 and 2.08 µM, respectively); crosses the blood brain barrier; increases survival in a U87 glioma mouse xenograft intracranial tumor model when orally administered at 20 and 40 mg/kg once per week

Catalog No. 50-295-1771 Supplier Cayman Chemical Supplier No. 115875 MG
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An inhibitor of the class I PI3K isoforms p110α (IC50 = 52 nM) and p110β (IC50 = 166 nM); selective for these isoforms over the class III PI3K Vps34 (IC50 = 2,410 nM), mTOR (IC50 = 2,866 nM), PI4Kβ (IC50 = >25,000 nM), and a variety of kinases (IC50s = >10,000 nM); inhibits proliferation of human tumor and glioma cell lines, with p53 wild-type glioma cells more sensitive than p53 mutant/deleted glioma cells (IC50s = 1.28 and 2.08 µM, respectively); crosses the blood brain barrier; increases survival in a U87 glioma mouse xenograft intracranial tumor model when orally administered at 20 and 40 mg/kg once per week

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