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Cayman Chemical ANTIBODY O12-D3-I3 10mg
SDP

Catalog No. 502944228
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An ionizable cationic lipid (pKa = 6.39); has been used in the generation of LNPs for siRNA delivery in vitro and in vivo; LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter decrease viability of HepG2 cells; LNPs containing O12-D3-I3 and an mRNA reporter selectively accumulate in the tumor and liver over the lungs, kidneys, spleen, and heart in mice; LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter reduce tumor growth and volume in an MCF-7 breast cancer mouse xenograft model; LNPs containing O12-D3-I3 and encapsulating siRNA targeting Factor VII decrease hepatocyte Factor VII mRNA levels in mice

Catalog No. 50-294-4228 Supplier Cayman Chemical Supplier No. 4138510 MG
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An ionizable cationic lipid (pKa = 6.39); has been used in the generation of LNPs for siRNA delivery in vitro and in vivo; LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter decrease viability of HepG2 cells; LNPs containing O12-D3-I3 and an mRNA reporter selectively accumulate in the tumor and liver over the lungs, kidneys, spleen, and heart in mice; LNPs containing O12-D3-I3 and encapsulating ferrocene and siRNA targeting Nrf2 or system xc- cystine/glutamate transporter reduce tumor growth and volume in an MCF-7 breast cancer mouse xenograft model; LNPs containing O12-D3-I3 and encapsulating siRNA targeting Factor VII decrease hepatocyte Factor VII mRNA levels in mice

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