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Cayman Chemical PD 166285, Purity: ≥98%, CAS: 185039-89-8, 10 mg
SDP

Catalog No. 502932963
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A tyrosine kinase inhibitor; inhibits Src, FGFR1, EGFR, and PDGFRβ (IC50s = 8.4, 39.3, 87.5, and 98.3 nM, respectively), as well as WEE1 (IC50 = 24 nM); inhibits PDGF- or EGF-induced receptor autophosphorylation in VSMCs and A431 cells, respectively, and bFGF-induced tyrosine phosphorylation in Sf9 cells (IC50s = 6.5, 1,600, and 97.3 nM, respectively); inhibits chemotaxis and growth of, as well as adhesion to vitronectin by, VSMCs (IC50s = 80-120 nM); inhibits radiation-induced cell cycle arrest at the G2/M phase and enhances radiation-induced cell death in HT-29 cells; inhibits angiogenesis and induces tumor regression in a 16c murine mammary carcinoma model when administered in combination with PDT at 1, 5, and 10 mg/kg

Catalog No. 50-293-2963 Supplier Cayman Chemical Supplier No. 2680410 MG
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A tyrosine kinase inhibitor; inhibits Src, FGFR1, EGFR, and PDGFRβ (IC50s = 8.4, 39.3, 87.5, and 98.3 nM, respectively), as well as WEE1 (IC50 = 24 nM); inhibits PDGF- or EGF-induced receptor autophosphorylation in VSMCs and A431 cells, respectively, and bFGF-induced tyrosine phosphorylation in Sf9 cells (IC50s = 6.5, 1,600, and 97.3 nM, respectively); inhibits chemotaxis and growth of, as well as adhesion to vitronectin by, VSMCs (IC50s = 80-120 nM); inhibits radiation-induced cell cycle arrest at the G2/M phase and enhances radiation-induced cell death in HT-29 cells; inhibits angiogenesis and induces tumor regression in a 16c murine mammary carcinoma model when administered in combination with PDT at 1, 5, and 10 mg/kg

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