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Cayman Chemical PD 166866, Purity: ≥98%, CAS: 192705-79-6, 5 mg
SDP

Catalog No. 502987867
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A potent inhibitor of FGFR1 (IC50 = 52.4 nM; Ki = 45.2 nM); selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 μM); inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and 3.1 nM, respectively); inhibits phosphorylation of MAPK (IC50 = 4.3 and 7.9 nM for the 44- and 42-kDa MAPK isoforms, respectively); reduces FGF- but not EGF- or PDGF-stimulated growth of L6 cells and inhibits microvessel outgrowth from human placental arteries in vitro; inhibits growth of NSCLC cell lines a dose-dependent manner; reduces migration of VL-8 cells at a concentration of 10 μM

Catalog No. 50-298-7867 Supplier Cayman Chemical Supplier No. 224645 MG
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A potent inhibitor of FGFR1 (IC50 = 52.4 nM; Ki = 45.2 nM); selective for FGFR1 over PDGFR, EGFR, C-SRC, MEK, PKC, insulin receptor tyrosine kinase, and CDK4 (IC50s = >50 μM); inhibits FGFR1 autophosphorylation in NIH3T3 and L6 cells (IC50s = 10.8 and 3.1 nM, respectively); inhibits phosphorylation of MAPK (IC50 = 4.3 and 7.9 nM for the 44- and 42-kDa MAPK isoforms, respectively); reduces FGF- but not EGF- or PDGF-stimulated growth of L6 cells and inhibits microvessel outgrowth from human placental arteries in vitro; inhibits growth of NSCLC cell lines a dose-dependent manner; reduces migration of VL-8 cells at a concentration of 10 μM

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