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Cayman Chemical ANTIBODY PF-249 5mg
Supplier: Cayman Chemical 384165 MG
An allosteric activator of AMPKβ1 heterotrimers (EC50s = 8 and 6 nM for human AMPK α1β1γ1 and -α2β1γ1, respectively); selective for AMPK α1β1γ1 and α2β1γ1 over AMPK α1β2γ1, -α2β2γ1, and -α2β2γ3 at 40 µM and a panel of receptors, channels, and phosphodiesterases at 10 µM; decreases proteinuria and improves kidney function in an obese ZSF1 rat model of diabetic nephropathy in a dose-dependent manner
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