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Cayman Chemical ANTIBODY PF-4693627 500ug
Supplier: Cayman Chemical 22768500 UG
An orally bioavailable mPGES-1 inhibitor (IC50 = 3 nM); selective for mPGES-1 over PGDS, TXAS, and 5-LO in HWB-1483 cells, which have IC50 values >50 μM, as well as COX-2 in fetal fibroblasts (IC50 = >10 μM); inhibits LPS-stimulated synthesis of PGE2 in human whole blood (IC50 = 109 nM); inhibits PGE2 production in a guinea pig model of carrageenan-induced air pouch inflammation (10 mg/kg)
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